Simeon Stafford was born in Duckinfield, a small northern town outside Manchester, and attended West Hill Boys' Secondary School, Staleybridge where he developed his deep interest in art. His work was constantly on display and at the age of 14 he was introduced to L.S.Lowry after winning the Robert Owen School Award for Art and the Manchester News Portrait Award. Lowry became a friend of the family and encouraged him to study art.
In 1972 and 1973, he studied at Hyde College and in 1974, became a professional artist and exhibited his work in mixed exhibitions throughout the north of England and London. His work at this time reflected the gritty northern landscape and characters in what has been called a primitive style. In 1996 he moved to Cornwall where he met the St Ives artists Terry Frost and Patrick Heron whose use of colour and light had a great impact on him.